Recent advances in senescence-associated secretory phenotype and osteoporosis
Haonan Fan,
Zhi Qiao,
Jitian Li,
Guowei Shang,
Chunfeng Shang,
Songfeng Chen,
Zikuan Leng,
Huifang Su,
Hongwei Kou,
Hongjian Liu
Affiliations
Haonan Fan
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Zhi Qiao
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Jitian Li
Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital)/Henan Institute of Orthopedic and Traumatology, Luoyang 471000, China
Guowei Shang
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Chunfeng Shang
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Songfeng Chen
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Zikuan Leng
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Huifang Su
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Hongwei Kou
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China; Corresponding author. Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hongjian Liu
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China; Corresponding author. Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age. The senescence-associated secretory phenotype (SASP), an essential cellular senescence hallmark, is an important mechanism connecting cellular senescence to osteoporosis. This review describes in detail the characteristics of SASPs and their regulatory agencies, and shed fresh light on how SASPs from different senescent cells contribute to osteoporosis development. Furthermore, we summarized various innovative therapy techniques that target SASPs to lower the burden of osteoporosis in the elderly and discussed the potential challenges of SASPs-based therapy for osteoporosis as a new clinical trial.
