Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract

Philip Burnham; Darshana Dadhania; Michael Heyang; Fanny Chen; Lars F. Westblade; Manikkam Suthanthiran; John Richard Lee; Iwijn De Vlaminck

doi:10.1038/s41467-018-04745-0

Nature Communications (Jun 2018)

Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract

Philip Burnham,
Darshana Dadhania,
Michael Heyang,
Fanny Chen,
Lars F. Westblade,
Manikkam Suthanthiran,
John Richard Lee,
Iwijn De Vlaminck

Affiliations

Philip Burnham: Meinig School of Biomedical Engineering, Cornell University
Darshana Dadhania: Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
Michael Heyang: Meinig School of Biomedical Engineering, Cornell University
Fanny Chen: Meinig School of Biomedical Engineering, Cornell University
Lars F. Westblade: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
Manikkam Suthanthiran: Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
John Richard Lee: Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine
Iwijn De Vlaminck: Meinig School of Biomedical Engineering, Cornell University

DOI: https://doi.org/10.1038/s41467-018-04745-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Urinary tract infections are one of the most common infections in humans. Here, the authors use urinary cell-free DNA (cfDNA) to comprehensively monitor host and pathogen dynamics in bacterial and viral urinary tract infections, and show that it is a versatile analyte for monitoring urinary tract infections.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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