Molecules (Jul 2010)

Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

  • Rosario González-Muñiz,
  • Antonio Ferrer-Montiel,
  • Asia Fernández-Carvajal,
  • Fernando Albericio,
  • Laura Zaccaro,
  • Miriam Royo,
  • Mª Teresa García-López,
  • Mª Jesús Pérez de Vega

DOI
https://doi.org/10.3390/molecules15074924
Journal volume & issue
Vol. 15, no. 7
pp. 4924 – 4933

Abstract

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Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.

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