Detection of SARS-CoV-2 in subcutaneous fat but not visceral fat, and the disruption of fat lymphocyte homeostasis in both fat tissues in the macaque

Anaëlle Olivo; Romain Marlin; Thierry Lazure; Pauline Maisonnasse; Laetitia Bossevot; Christelliah Mouanga; Julien Lemaitre; Guillaume Pourcher; Stéphane Benoist; Roger Le Grand; Olivier Lambotte; Nathalie Dereuddre-Bosquet; Christine Bourgeois

doi:10.1038/s42003-022-03503-9

Communications Biology (Jun 2022)

Detection of SARS-CoV-2 in subcutaneous fat but not visceral fat, and the disruption of fat lymphocyte homeostasis in both fat tissues in the macaque

Anaëlle Olivo,
Romain Marlin,
Thierry Lazure,
Pauline Maisonnasse,
Laetitia Bossevot,
Christelliah Mouanga,
Julien Lemaitre,
Guillaume Pourcher,
Stéphane Benoist,
Roger Le Grand,
Olivier Lambotte,
Nathalie Dereuddre-Bosquet,
Christine Bourgeois

Affiliations

Anaëlle Olivo: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)
Romain Marlin: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)
Thierry Lazure: Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’anatomo-pathologie
Pauline Maisonnasse: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)
Laetitia Bossevot: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)
Christelliah Mouanga: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)
Julien Lemaitre: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)
Guillaume Pourcher: Obesity Center, Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris
Stéphane Benoist: Assistance Publique-Hôpitaux de Paris, GHU Paris-Saclay, Hôpital Bicêtre, Service de Chirurgie Digestive et Oncologique
Roger Le Grand: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)
Olivier Lambotte: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)
Nathalie Dereuddre-Bosquet: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)
Christine Bourgeois: Université Paris-Saclay, CEA, INSERM UMR-1184, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT)

DOI: https://doi.org/10.1038/s42003-022-03503-9
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

Read online

Subcutaneous fat tissue expresses higher angiotensin-converting-enzyme 2 mRNA than visceral fat tissue and is selectively infected by SARS-Cov-2, while both fat tissues show drastic reduction in CD69 expression in T cells.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal