Nature Communications (Mar 2023)

Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis

  • Shane T. Killarney,
  • Rachel Washart,
  • Ryan S. Soderquist,
  • Jacob P. Hoj,
  • Jamie Lebhar,
  • Kevin H. Lin,
  • Kris C. Wood

DOI
https://doi.org/10.1038/s41467-023-37146-z
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 13

Abstract

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During apoptosis, mitochondrial outer membrane permeabilization results in cytosolic mitochondrial RNA (mtRNA). Here, the authors demonstrate that caspase-3/7 inhibition promotes a cytosolic mtRNA-driven Type I interferon response via MDA5/MAVS/IRF3, increasing the immunogenicity of chemotherapy-induced apoptosis.