An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair

Jiacheng Guo; Zhenzhen Yang; Yongzheng Lu; Chunyan Du; Chang Cao; Bo Wang; Xiaoting Yue; Zenglei Zhang; Yanyan Xu; Zhen Qin; Tingting Huang; Wei Wang; Wei Jiang; Jinying Zhang; Junnan Tang

Bioactive Materials (Apr 2022)

An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair

Jiacheng Guo,
Zhenzhen Yang,
Yongzheng Lu,
Chunyan Du,
Chang Cao,
Bo Wang,
Xiaoting Yue,
Zenglei Zhang,
Yanyan Xu,
Zhen Qin,
Tingting Huang,
Wei Wang,
Wei Jiang,
Jinying Zhang,
Junnan Tang

Affiliations

Jiacheng Guo: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China
Zhenzhen Yang: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China
Yongzheng Lu: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China
Chunyan Du: Laboratory Animal Center, School of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, 450052, China
Chang Cao: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China
Bo Wang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China
Xiaoting Yue: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China
Zenglei Zhang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China
Yanyan Xu: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China
Zhen Qin: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China
Tingting Huang: Department of Polymer Science, College of Chemistry, Jilin University, Changchun, Jilin, 130012, China
Wei Wang: Henan Medical Association, Zhengzhou, Henan, 450052, China
Wei Jiang: Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan, 450052, China; Corresponding author. No.40 North Road, 27 District University, Zhengzhou, Henan, 450052, China.
Jinying Zhang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China; Corresponding author. No.1 Eastern Jianshe Road, Zhengzhou, Henan, 450052, China.
Junnan Tang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, Henan, 450018, China; Corresponding author. No.1 Eastern Jianshe Road, Zhengzhou, Henan, 450052, China.

Journal volume & issue: Vol. 10
pp. 56 – 67

Abstract

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Acute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme with Superoxide Dismutase (SOD) activity cross-link with Zr-based metal-organic framework (ZrMOF) (SOD-ZrMOF) for mitigate ROS-caused injury. In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility. By efficiently scavenging ROS and suppressing oxidative stress, SOD-ZrMOF can protect the function of mitochondria, reduce cell death and alleviate inflammation. More excitingly, long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area, protect cardiac function, promote angiogenesis and inhibit pathological myocardial remodeling. Therefore, SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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