The implication of pyroptosis in cancer immunology: Current advances and prospects

Wei Liu; Jinwu Peng; Muzhang Xiao; Yuan Cai; Bi Peng; Wenqin Zhang; Jianbo Li; Fanhua Kang; Qianhui Hong; Qiuju Liang; Yuanliang Yan; Zhijie Xu

Genes and Diseases (Nov 2023)

The implication of pyroptosis in cancer immunology: Current advances and prospects

Wei Liu,
Jinwu Peng,
Muzhang Xiao,
Yuan Cai,
Bi Peng,
Wenqin Zhang,
Jianbo Li,
Fanhua Kang,
Qianhui Hong,
Qiuju Liang,
Yuanliang Yan,
Zhijie Xu

Affiliations

Wei Liu: Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Orthopedic Surgery, The Second Hospital University of South China, Hengyang, Hunan 421001, China
Jinwu Peng: Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Pathology, Xiangya Changde Hospital, Changde, Hunan 415000, China
Muzhang Xiao: Department of Burn and Plastic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Yuan Cai: Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Corresponding author. Fax: +86 73184327291.
Bi Peng: Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Wenqin Zhang: Department of Pathology, Xiangya Changde Hospital, Changde, Hunan 415000, China
Jianbo Li: Department of Pathology, Xiangya Changde Hospital, Changde, Hunan 415000, China
Fanhua Kang: Department of Pathology, Xiangya Changde Hospital, Changde, Hunan 415000, China
Qianhui Hong: Department of Pathology, Xiangya Changde Hospital, Changde, Hunan 415000, China
Qiuju Liang: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Yuanliang Yan: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Zhijie Xu: Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Pathology, Xiangya Changde Hospital, Changde, Hunan 415000, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Corresponding author. Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Fax: +86 73184327291.

Journal volume & issue: Vol. 10, no. 6
pp. 2339 – 2350

Abstract

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Pyroptosis is a regulated cell death pathway involved in numerous human diseases, especially malignant tumors. Recent studies have identified multiple pyroptosis-associated signaling molecules, like caspases, gasdermin family and inflammasomes. In addition, increasing in vitro and in vivo studies have shown the significant linkage between pyroptosis and immune regulation of cancers. Pyroptosis-associated biomarkers regulate the infiltration of tumor immune cells, such as CD4+ and CD8+ T cells, thus strengthening the sensitivity to therapeutic strategies. In this review, we explained the relationship between pyroptosis and cancer immunology and focused on the significance of pyroptosis in immune regulation. We also proposed the future application of pyroptosis-associated biomarkers in basic research and clinical practices to address malignant behaviors. Exploration of the underlying mechanisms and biological functions of pyroptosis is critical for immune response and cancer immunotherapy.

Published in Genes and Diseases

ISSN: 2352-3042 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/genes-and-diseases/

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