Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site
Mengqi Dong,
Fang Liu,
Hongyu Zhou,
Shumei Zhai,
Bing Yan
Affiliations
Mengqi Dong
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
Fang Liu
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
Hongyu Zhou
School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China
Shumei Zhai
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
Bing Yan
School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China
Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side-effects, and generally poor bioavailability. Thus, there is a constant need to search for novel tubulin inhibitors that can overcome these limitations. Natural product and privileged structures targeting tubulin have promoted the discovery and optimization of tubulin inhibitors. This review will focus on novel tubulin inhibitors derived from natural products and privileged structures targeting the colchicine binding site on tubulin.
