Nature Communications (Nov 2022)
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration
- Allah Nawaz,
- Muhammad Bilal,
- Shiho Fujisaka,
- Tomonobu Kado,
- Muhammad Rahil Aslam,
- Saeed Ahmed,
- Keisuke Okabe,
- Yoshiko Igarashi,
- Yoshiyuki Watanabe,
- Takahide Kuwano,
- Koichi Tsuneyama,
- Ayumi Nishimura,
- Yasuhiro Nishida,
- Seiji Yamamoto,
- Masakiyo Sasahara,
- Johji Imura,
- Hisashi Mori,
- Martin M. Matzuk,
- Fujimi Kudo,
- Ichiro Manabe,
- Akiyoshi Uezumi,
- Takashi Nakagawa,
- Yumiko Oishi,
- Kazuyuki Tobe
Affiliations
- Allah Nawaz
- Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
- Muhammad Bilal
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- Shiho Fujisaka
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- Tomonobu Kado
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- Muhammad Rahil Aslam
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- Saeed Ahmed
- Department of Medicine and Surgery, Rawalpindi Medical University
- Keisuke Okabe
- Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
- Yoshiko Igarashi
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- Yoshiyuki Watanabe
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- Takahide Kuwano
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- Koichi Tsuneyama
- Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
- Ayumi Nishimura
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- Yasuhiro Nishida
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- Seiji Yamamoto
- Department of Pathology, Faculty of Medicine, University of Toyama
- Masakiyo Sasahara
- Department of Pathology, Faculty of Medicine, University of Toyama
- Johji Imura
- Department of Diagnostic Pathology, Faculty of Medicine, University of Toyama
- Hisashi Mori
- Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
- Martin M. Matzuk
- Department of Pathology and Immunology, Baylor College of Medicine
- Fujimi Kudo
- Department of Systems Medicine, Chiba University Graduate School of Medicine
- Ichiro Manabe
- Department of Systems Medicine, Chiba University Graduate School of Medicine
- Akiyoshi Uezumi
- Department of Nutritional Physiology, Graduate School of Biomedical Sciences, Tokushima University
- Takashi Nakagawa
- Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama
- Yumiko Oishi
- Department of Biochemistry and Molecular Biology, Nippon Medical School
- Kazuyuki Tobe
- First Department of Internal Medicine, Faculty of Medicine, University of Toyama
- DOI
- https://doi.org/10.1038/s41467-022-34191-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Muscle regeneration requires the contribution and communication of various different cell types. Here, Nawaz et al. show that CD206+ macrophages inhibit the secretion of the promyogenic factor follistatin by fibro-adipogenic progenitor cells, impeding myogenesis and muscle regeneration.
