Bilateral tubulocystic renal cell carcinomas in diabetic end-stage renal disease: first case report with cytogenetic and ultrastructural studies
Max Xiangtian Kong,
Christopher Hale,
Antonio Subietas-Mayol,
Peng Lee,
Nicholas D. Cassai,
Gerald McRae,
David S. Goldfarb,
Ming Zhou,
Rosemary Wieczorek
Affiliations
Max Xiangtian Kong
Department of Pathology, New York Harbor VA Medical Center, New York University School of Medicine, NY
Christopher Hale
Department of Pathology, New York Harbor VA Medical Center, New York University School of Medicine, NY
Antonio Subietas-Mayol
Department of Pathology, New York Harbor VA Medical Center, New York University School of Medicine, NY
Peng Lee
Department of Pathology, New York Harbor VA Medical Center, New York University School of Medicine, NY
Nicholas D. Cassai
Department of Pathology, New York Harbor VA Medical Center, New York University School of Medicine, NY
Gerald McRae
Department of Pathology, New York Harbor VA Medical Center, New York University School of Medicine, NY
David S. Goldfarb
Department of Medicine, New York Harbor VA Medical Center, New York University School of Medicine, NY
Ming Zhou
Department of Pathology, New York Harbor VA Medical Center, New York University School of Medicine, NY; Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH
Rosemary Wieczorek
Department of Pathology, New York Harbor VA Medical Center, New York University School of Medicine, NY
Tubulocystic renal cell carcinoma (TC-RCC) is a rare renal tumor composed of well-differentiated tubules and cysts lined by neoplastic cells with eosinophilic cytoplasm and prominent nucleoli. The origin of the tumor cells is still controversial. TC-RCC typically arises unilaterally. Involvement of both kidneys by multifocal TC-RCC has not been reported. In this study we report the first case of bilateral and multifocal TC-RCC. Immunohistochemical, cytogenetic and ultrastructural studies suggest TC-RCC is closely related to papillary RCC.
