Nature Communications (Jan 2017)

Cell-like pressure sensors reveal increase of mechanical stress towards the core of multicellular spheroids under compression

  • M. E. Dolega,
  • M. Delarue,
  • F. Ingremeau,
  • J. Prost,
  • A. Delon,
  • G. Cappello

DOI
https://doi.org/10.1038/ncomms14056
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Quantifying the propagation of mechanical stress in multicellular tissues remains challenging. Here the authors develop polyacrylamide microbeads as sensors that accurately report on stress within spheroids and show that external compression results in a rise in pressure towards the core.