Molecular definition of group 1 innate lymphoid cells in the mouse uterus

Iva Filipovic; Laura Chiossone; Paola Vacca; Russell S. Hamilton; Tiziano Ingegnere; Jean-Marc Doisne; Delia A. Hawkes; Maria Cristina Mingari; Andrew M. Sharkey; Lorenzo Moretta; Francesco Colucci

doi:10.1038/s41467-018-06918-3

Nature Communications (Oct 2018)

Molecular definition of group 1 innate lymphoid cells in the mouse uterus

Iva Filipovic,
Laura Chiossone,
Paola Vacca,
Russell S. Hamilton,
Tiziano Ingegnere,
Jean-Marc Doisne,
Delia A. Hawkes,
Maria Cristina Mingari,
Andrew M. Sharkey,
Lorenzo Moretta,
Francesco Colucci

Affiliations

Iva Filipovic: Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre
Laura Chiossone: G. Gaslini Institute, Genoa
Paola Vacca: Policlinico San Martino IRCCS per l’Oncologia, Genoa
Russell S. Hamilton: Centre for Trophoblast Research, University of Cambridge
Tiziano Ingegnere: Department of Immunology, IRCCS Bambino Gesù Children’s Hospital
Jean-Marc Doisne: Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre
Delia A. Hawkes: Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre
Maria Cristina Mingari: Policlinico San Martino IRCCS per l’Oncologia, Genoa
Andrew M. Sharkey: Centre for Trophoblast Research, University of Cambridge
Lorenzo Moretta: Department of Immunology, IRCCS Bambino Gesù Children’s Hospital
Francesco Colucci: Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre

DOI: https://doi.org/10.1038/s41467-018-06918-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Studying the uterine lymphocyte pool is difficult due to its dynamic nature induced by various pregnancy-related factors. Here the authors provide, using transcriptome data from sorted mouse group 1 innate lymphoid cells (ILC), a molecular atlas of these cells, which implicates tissue-resident natural killer cells as a hub for uterine immune crosstalk.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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