Mesoporous additive-free vaterite CaCO3 crystals of untypical sizes: From submicron to Giant

Anna Vikulina; Joseph Webster; Denis Voronin; Evgenii Ivanov; Rawil Fakhrullin; Vladimir Vinokurov; Dmitry Volodkin

Materials & Design (Jan 2021)

Mesoporous additive-free vaterite CaCO3 crystals of untypical sizes: From submicron to Giant

Anna Vikulina,
Joseph Webster,
Denis Voronin,
Evgenii Ivanov,
Rawil Fakhrullin,
Vladimir Vinokurov,
Dmitry Volodkin

Affiliations

Anna Vikulina: Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses, Am Mühlenberg 13, 14476 Potsdam-Golm, Germany; Corresponding author.
Joseph Webster: Nottingham Trent University, School of Science and Technology, Clifton Lane, NG11 8NS Nottingham, UK
Denis Voronin: Gubkin Russian State University of oil and gas, Department of physical chemistry, Leninsky pr. 65-1, Moscow 119991, Russian Federation; Saratov State University, Educational and Research Institute of Nanostructures and Biosystems, Astrakhanskaya st. 83, Saratov 410012, Russian Federation
Evgenii Ivanov: Gubkin Russian State University of oil and gas, Department of physical chemistry, Leninsky pr. 65-1, Moscow 119991, Russian Federation
Rawil Fakhrullin: Gubkin Russian State University of oil and gas, Department of physical chemistry, Leninsky pr. 65-1, Moscow 119991, Russian Federation; Kazan Federal University, Institute of Fundamental Medicine and Biology, Kreml uramı 18, Kazan, Republic of Tatarstan, 420008, Russian Federation
Vladimir Vinokurov: Gubkin Russian State University of oil and gas, Department of physical chemistry, Leninsky pr. 65-1, Moscow 119991, Russian Federation
Dmitry Volodkin: Nottingham Trent University, School of Science and Technology, Clifton Lane, NG11 8NS Nottingham, UK; Gubkin Russian State University of oil and gas, Department of physical chemistry, Leninsky pr. 65-1, Moscow 119991, Russian Federation

Journal volume & issue: Vol. 197
p. 109220

Abstract

Read online

Mesoporous CaCO3 crystals of sizes in the range 3–15 μm have attracted significant scientific attention as fully decomposable biocompatible drug delivery vectors. They are also used as sacrificial templates to produce polymer-based microcarriers (capsules, beads) and polymer scaffolds for tissue engineering at biologically friendly conditions. However, fabrication of CaCO3 crystals with the sizes beyond the conventional range without additives is still a challenge. There is a desperate need of sub-micrometre and sub-millimetre biocompatible and easily decomposable vectors for intracellular delivery and design of tailor-made polymer scaffolds, respectively. In this study, additive-free one-step fabrication of vaterite mesoporous crystals with sizes in the range from submicron (0.72 μm) up to tens of microns (55 μm) sizes is proposed. Crystals are grown by mixing of Ca2+ and CO32− salts in aqueous media. Internal structure and morphology of the crystals have been investigated. Encapsulation of lysozyme by means of co-synthesis shows an enhanced entrapment into submicron crystals. Besides, the approach to grow CaCO3 crystals on the surface of microcellulose ьш is demonstrated opening broad avenues for the development of vaterite coatings technologies.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

About the journal

Abstract

Keywords