Nature Communications (Sep 2020)
DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
- Ake T. Lu,
- Pritika Narayan,
- Matthew J. Grant,
- Peter Langfelder,
- Nan Wang,
- Seung Kwak,
- Hilary Wilkinson,
- Richard Z. Chen,
- Jian Chen,
- C. Simon Bawden,
- Skye R. Rudiger,
- Marc Ciosi,
- Afroditi Chatzi,
- Alastair Maxwell,
- Timothy A. Hore,
- Jeff Aaronson,
- Jim Rosinski,
- Alicia Preiss,
- Thomas F. Vogt,
- Giovanni Coppola,
- Darren Monckton,
- Russell G. Snell,
- X. William Yang,
- Steve Horvath
Affiliations
- Ake T. Lu
- Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
- Pritika Narayan
- Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland
- Matthew J. Grant
- Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland
- Peter Langfelder
- Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA)
- Nan Wang
- Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA)
- Seung Kwak
- CHDI Management/CHDI Foundation
- Hilary Wilkinson
- CHDI Management/CHDI Foundation
- Richard Z. Chen
- CHDI Management/CHDI Foundation
- Jian Chen
- CHDI Management/CHDI Foundation
- C. Simon Bawden
- Livestock and Farming Systems, South Australian Research and Development Institute
- Skye R. Rudiger
- Livestock and Farming Systems, South Australian Research and Development Institute
- Marc Ciosi
- Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Afroditi Chatzi
- Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Alastair Maxwell
- Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Timothy A. Hore
- Department of Anatomy, University of Otago
- Jeff Aaronson
- CHDI Management/CHDI Foundation
- Jim Rosinski
- CHDI Management/CHDI Foundation
- Alicia Preiss
- CHDI Management/CHDI Foundation
- Thomas F. Vogt
- CHDI Management/CHDI Foundation
- Giovanni Coppola
- Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA)
- Darren Monckton
- Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Russell G. Snell
- Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland
- X. William Yang
- Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA)
- Steve Horvath
- Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
- DOI
- https://doi.org/10.1038/s41467-020-18255-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Although Huntington’s disease (HD) is a well-studied genetic disorder, less is known about the epigenetic changes underlying it. Here, the authors characterize DNA methylation levels in tissues from patients, a mouse huntingtin (Htt) gene knock-in model, and a transgenic HTT sheep model, and provide evidence that HD is accompanied by DNA methylation changes in these three species.
