Nature Communications (Nov 2022)
Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly
- Peggy Riese,
- Stephanie Trittel,
- Manas K. Akmatov,
- Marcus May,
- Jana Prokein,
- Thomas Illig,
- Christoph Schindler,
- Birgit Sawitzki,
- Yassin Elfaki,
- Stefan Floess,
- Jochen Huehn,
- Adrian J. Błażejewski,
- Till Strowig,
- Esteban A. Hernandez-Vargas,
- Robert Geffers,
- Bowen Zhang,
- Yang Li,
- Frank Pessler,
- Carlos A. Guzmán
Affiliations
- Peggy Riese
- Department Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI)
- Stephanie Trittel
- Department Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI)
- Manas K. Akmatov
- Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Medicine
- Marcus May
- Center for Clinical Trials (ZKS), Early Clinical Trial Unit, Hannover Medical School
- Jana Prokein
- Hannover Unified Biobank, Hannover Medical School
- Thomas Illig
- Hannover Unified Biobank, Hannover Medical School
- Christoph Schindler
- Center for Clinical Trials (ZKS), Early Clinical Trial Unit, Hannover Medical School
- Birgit Sawitzki
- Institute of Medical Immunology, Charité-Universitätsmedizin, Campus Virchow-Klinikum, Augustenburger Pl. 1
- Yassin Elfaki
- Department Experimental Immunology, Helmholtz Centre for Infection Research (HZI)
- Stefan Floess
- Department Experimental Immunology, Helmholtz Centre for Infection Research (HZI)
- Jochen Huehn
- Department Experimental Immunology, Helmholtz Centre for Infection Research (HZI)
- Adrian J. Błażejewski
- Department Microbial Immune Regulation, Helmholtz Centre for Infection Research (HZI)
- Till Strowig
- Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Medicine
- Esteban A. Hernandez-Vargas
- Department of Mathematics and Statistical Science, University of Idaho
- Robert Geffers
- RG Genome Analytics, Helmholtz Centre for Infection Research (HZI)
- Bowen Zhang
- Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM)
- Yang Li
- Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM)
- Frank Pessler
- Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Medicine
- Carlos A. Guzmán
- Department Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI)
- DOI
- https://doi.org/10.1038/s41467-022-34487-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Seasonal influenza vaccination is an important strategy to prevent serious disease in the elderly, but individual responsiveness to vaccination widely vary. Here authors establish, with an array of state-of-the art methods, the major immunological parameters that distinguish vaccine recipients developing robust antibody response and non-responders
