Viruses
(Aug 2024)
Predominance of Dengue Virus Serotype-1/Genotype-I in Eastern and Southeastern Ethiopia
Mesfin Mengesha Tsegaye,
Adamu Tayachew Mekonnen,
Daniel Tsega Gebretsion,
Tesfaye Gelanew,
Dawit Hailu Alemayehu,
Dessalegn Abeje Tefera,
Tamirayehu Seyoum Woldemichael,
Bethlehem Adnew Getaneh,
Eleni Kidane Abera,
Gadissa Gutema Jebessa,
Asefa Konde Korkiso,
Mengistu Biru Tessema,
Admikew Agunie Asfaw,
Yoseph Asrat Temre,
Mesfin Wossen,
Anne Piantadosi,
Huachen Zhu,
Alemseged Abdissa,
Adane Mihret,
Andargachew Mulu
Affiliations
Mesfin Mengesha Tsegaye
Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia
Adamu Tayachew Mekonnen
Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia
Daniel Tsega Gebretsion
Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia
Tesfaye Gelanew
Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia
Dawit Hailu Alemayehu
Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia
Dessalegn Abeje Tefera
Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia
Tamirayehu Seyoum Woldemichael
Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia
Bethlehem Adnew Getaneh
Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia
Eleni Kidane Abera
Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia
Gadissa Gutema Jebessa
Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia
Asefa Konde Korkiso
Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia
Mengistu Biru Tessema
Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia
Admikew Agunie Asfaw
Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia
Yoseph Asrat Temre
Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia
Mesfin Wossen
Public Health Emergency Management Center, Ethiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia
Anne Piantadosi
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Huachen Zhu
State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong SAR 999077, China
Alemseged Abdissa
Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia
Adane Mihret
Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia
Andargachew Mulu
Viral Diseases Research Division, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia
DOI
https://doi.org/10.3390/v16081334
Journal volume & issue
Vol. 16,
no. 8
Abstract
Read online
We determined the dengue virus (DENV) serotypes and genotypes in archived serum samples that were collected during the 2014–2016 and 2021 dengue outbreaks in Dire Dawa City and the Somali region in Ethiopia. DENV serotype 1 (DENV-1) was predominant followed by DENV serotype 2 (DENV-2). Thirteen of the DENV-1 strains were assigned to Genotype-I, while the remaining two were found to be Genotype-III. All three DENV-2 strains were assigned the Cosmopolitan Genotype. The DENV strains responsible for the outbreaks are genetically closely related to the DENV strains that circulated in neighboring and Asian countries. The findings also showed continued local transmission of a monophyletic lineage and a co-circulation of DENV-1 and DENV-2 during the outbreaks. There is a need to strengthen DENV genomic surveillance capacity for the early detection of circulating serotypes, and prevent devastating consequences of future outbreaks due to the co-circulation of different serotypes.
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