Nature Communications (Mar 2018)

Large enhancement of response times of a protein conformational switch by computational design

  • Alex J. DeGrave,
  • Jeung-Hoi Ha,
  • Stewart N. Loh,
  • Lillian T. Chong

DOI
https://doi.org/10.1038/s41467-018-03228-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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The rational optimization of response times of protein conformational switches is a major challenge for biomolecular switch design. Here the authors present a generally applicable computational design strategy that in combination with biophysical experiments can improve response times using a Ca2+-sensor as an example.