Health position paper and redox perspectives - Disease burden by transportation noise
Mette Sørensen,
Göran Pershagen,
Jesse Daniel Thacher,
Timo Lanki,
Benedikt Wicki,
Martin Röösli,
Danielle Vienneau,
Manuella Lech Cantuaria,
Jesper Hvass Schmidt,
Gunn Marit Aasvang,
Sadeer Al-Kindi,
Michael T. Osborne,
Philip Wenzel,
Juan Sastre,
Ingrid Fleming,
Rainer Schulz,
Omar Hahad,
Marin Kuntic,
Jacek Zielonka,
Helmut Sies,
Tilman Grune,
Katie Frenis,
Thomas Münzel,
Andreas Daiber
Affiliations
Mette Sørensen
Work, Environment and Cancer, Danish Cancer Institute, Copenhagen, Denmark; Department of Natural Science and Environment, Roskilde University, Denmark; Corresponding author. Work, Environment and Cancer, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Göran Pershagen
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Jesse Daniel Thacher
Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden
Timo Lanki
Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland; School of Medicine, University of Eastern Finland, Kuopio, Finland; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland
Benedikt Wicki
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland
Martin Röösli
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland
Danielle Vienneau
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland
Manuella Lech Cantuaria
Work, Environment and Cancer, Danish Cancer Institute, Copenhagen, Denmark; Research Unit for ORL – Head & Neck Surgery and Audiology, Odense University Hospital & University of Southern Denmark, Odense, Denmark
Jesper Hvass Schmidt
Research Unit for ORL – Head & Neck Surgery and Audiology, Odense University Hospital & University of Southern Denmark, Odense, Denmark
Gunn Marit Aasvang
Department of Air Quality and Noise, Norwegian Institute of Public Health, Oslo, Norway
Sadeer Al-Kindi
Department of Medicine, University Hospitals, Harrington Heart & Vascular Institute, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH, 44106, USA
Michael T. Osborne
Cardiovascular Imaging Research Center, Massachusetts General Hospital, Boston, MA, USA; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
Philip Wenzel
Department of Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany
Juan Sastre
Department of Physiology, Faculty of Pharmacy, University of Valencia, Spain
Ingrid Fleming
Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt Am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany
Rainer Schulz
Institute of Physiology, Faculty of Medicine, Justus-Liebig University, Gießen, 35392, Gießen, Germany
Omar Hahad
Department of Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany
Marin Kuntic
Department of Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany
Jacek Zielonka
Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA
Helmut Sies
Institute for Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
Tilman Grune
Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany
Katie Frenis
Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA
Thomas Münzel
Department of Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany
Andreas Daiber
Department of Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany; Corresponding author. University Medical Center Mainz, Department of Cardiology, Cardiology I, Geb. 605, Langenbeckstr. 1, 55131, Mainz, Germany.
Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart disease. In contrast, they concluded that the quality of evidence for a link to other diseases was very low to moderate. Since then, several studies on the impact of noise on various diseases have been published. Also, studies investigating the mechanistic pathways underlying noise-induced health effects are emerging. We review the current evidence regarding effects of noise on health and the related disease-mechanisms. Several high-quality cohort studies consistently found road traffic noise to be associated with a higher risk of ischemic heart disease, heart failure, diabetes, and all-cause mortality. Furthermore, recent studies have indicated that road traffic and railway noise may increase the risk of diseases not commonly investigated in an environmental noise context, including breast cancer, dementia, and tinnitus. The harmful effects of noise are related to activation of a physiological stress response and nighttime sleep disturbance. Oxidative stress and inflammation downstream of stress hormone signaling and dysregulated circadian rhythms are identified as major disease-relevant pathomechanistic drivers. We discuss the role of reactive oxygen species and present results from antioxidant interventions. Lastly, we provide an overview of oxidative stress markers and adverse redox processes reported for noise-exposed animals and humans. This position paper summarizes all available epidemiological, clinical, and preclinical evidence of transportation noise as an important environmental risk factor for public health and discusses its implications on the population level.
