In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells

Dajung Jung; Jie Xiong; Min Ye; Xunsi Qin; Lin Li; Shunfeng Cheng; Mengyuan Luo; Jia Peng; Ji Dong; Fuchou Tang; Wei Shen; Martin M. Matzuk; Kehkooi Kee

doi:10.1038/ncomms15680

Nature Communications (Jun 2017)

In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells

Dajung Jung,
Jie Xiong,
Min Ye,
Xunsi Qin,
Lin Li,
Shunfeng Cheng,
Mengyuan Luo,
Jia Peng,
Ji Dong,
Fuchou Tang,
Wei Shen,
Martin M. Matzuk,
Kehkooi Kee

Affiliations

Dajung Jung: Department of Basic Medical Sciences, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Jie Xiong: Department of Basic Medical Sciences, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Min Ye: Department of Basic Medical Sciences, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Xunsi Qin: Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University
Lin Li: Department of Basic Medical Sciences, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Shunfeng Cheng: Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University
Mengyuan Luo: Department of Basic Medical Sciences, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Jia Peng: Departments of Pathology & Immunology, Discovery, Baylor College of Medicine
Ji Dong: Biodynamic Optical Imaging Center & Department of Obstetrics and Gynecology, College of Life Sciences, Third Hospital, Peking University
Fuchou Tang: Biodynamic Optical Imaging Center & Department of Obstetrics and Gynecology, College of Life Sciences, Third Hospital, Peking University
Wei Shen: Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University
Martin M. Matzuk: Departments of Pathology & Immunology, Discovery, Baylor College of Medicine
Kehkooi Kee: Department of Basic Medical Sciences, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University

DOI: https://doi.org/10.1038/ncomms15680
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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In vitro production of human oocytes for the treatment of female infertility is a goal in reproductive medicine. Here, the authors establish in vitroconditions to generate human ovarian follicle-like cells from human embryonic stem cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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