Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO<sub>2</sub> Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque
Yuriy Gerasymchuk,
Wojciech Kałas,
Jacek Arkowski,
Łukasz Marciniak,
Dariusz Hreniak,
Edyta Wysokińska,
Leon Strządała,
Marta Obremska,
Larysa Tomachynski,
Viktor Chernii,
Wiesław Stręk
Affiliations
Yuriy Gerasymchuk
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, ul. Okólna 2, 50-422 Wrocław, Poland
Wojciech Kałas
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland
Jacek Arkowski
Department of Preclinical Studies, Wrocław Medical University, ul. K. Bartla 5, 51-618 Wrocław, Poland
Łukasz Marciniak
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, ul. Okólna 2, 50-422 Wrocław, Poland
Dariusz Hreniak
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, ul. Okólna 2, 50-422 Wrocław, Poland
Edyta Wysokińska
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland
Leon Strządała
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland
Marta Obremska
Department of Preclinical Studies, Wrocław Medical University, ul. K. Bartla 5, 51-618 Wrocław, Poland
Larysa Tomachynski
V.I. Vernadskii Institute of General and Inorganic Chemistry, 32/34 Palladin Ave., 03-142 Kyiv, Ukraine
Viktor Chernii
V.I. Vernadskii Institute of General and Inorganic Chemistry, 32/34 Palladin Ave., 03-142 Kyiv, Ukraine
Wiesław Stręk
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, ul. Okólna 2, 50-422 Wrocław, Poland
A new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO2 nanocarriers (SiO2-(CH2)3-NH2NPs), which may potentially be used in photodynamic therapy of atherosclerosis. Its structure and morphology have been investigated. The photochemical properties of the composite material has been characterized. in saline environments when exposed to different light sources Reactive oxygen species (ROS) generation in DMSO suspension under near IR irradiation was evaluated. The PcZrGallate-SiO2 conjugate has been found to induce a cytotoxic effect on macrophages after IR irradiation, which did not correspond to ROS production. It was found that SiO2 as a carrier helps the photosensitizer to enter into the macrophages, a type of cells that play a key role in the development of atheroma. These properties of the novel conjugate may make it useful in the photodynamic therapy of coronary artery disease.
