Understanding the Constraints and Optimization of Serum Immunofixation Electrophoresis and Serum Free Light Chains for Detecting Monoclonal Proteins: A Single-Center Experience

Malvika Shastri; Pankaj Malhotra; Harvinder Kaur; Ritu Aggarwal

doi:10.1055/s-0043-1768684

Journal of Laboratory Physicians (Dec 2023)

Understanding the Constraints and Optimization of Serum Immunofixation Electrophoresis and Serum Free Light Chains for Detecting Monoclonal Proteins: A Single-Center Experience

Malvika Shastri,
Pankaj Malhotra,
Harvinder Kaur,
Ritu Aggarwal

Affiliations

Malvika Shastri: ORCiD; Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Pankaj Malhotra: Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Harvinder Kaur: Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Ritu Aggarwal: Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

DOI: https://doi.org/10.1055/s-0043-1768684
Journal volume & issue: Vol. 15, no. 04
pp. 518 – 523

Abstract

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Introduction Serum immunofixation electrophoresis (SIFE) and serum free light chain (SFLC) assay are imperative investigations in diagnosis and follow-up of multiple myeloma (MM). SFLC assays are reported to have higher sensitivity than SIFE. However, discrepancies have been reported between them. The current study was aimed at assessing concordance and discordance between SIFE and SFLC results in MM.

Published in Journal of Laboratory Physicians

ISSN: 0974-2727 (Print); 0974-7826 (Online)
Publisher: Thieme Medical and Scientific Publishers Pvt. Ltd.
Country of publisher: India
LCC subjects: Medicine
Website: https://www.thieme.in/journal-of-laboratory-physicians

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