Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism

Yiqin Wang; Xiaoxian Guo; Xiumei Hong; Guoying Wang; Colleen Pearson; Barry Zuckerman; Andrew G. Clark; Kimberly O. O’Brien; Xiaobin Wang; Zhenglong Gu

doi:10.1038/s41467-022-30805-7

Nature Communications (Jul 2022)

Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism

Yiqin Wang,
Xiaoxian Guo,
Xiumei Hong,
Guoying Wang,
Colleen Pearson,
Barry Zuckerman,
Andrew G. Clark,
Kimberly O. O’Brien,
Xiaobin Wang,
Zhenglong Gu

Affiliations

Yiqin Wang: Division of Nutritional Sciences, Cornell University
Xiaoxian Guo: Division of Nutritional Sciences, Cornell University
Xiumei Hong: Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health
Guoying Wang: Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health
Colleen Pearson: Department of Pediatrics, Boston University School of Medicine and Boston Medical Center
Barry Zuckerman: Department of Pediatrics, Boston University School of Medicine and Boston Medical Center
Andrew G. Clark: Department of Molecular Biology and Genetics, Cornell University
Kimberly O. O’Brien: Division of Nutritional Sciences, Cornell University
Xiaobin Wang: Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health
Zhenglong Gu: Division of Nutritional Sciences, Cornell University

DOI: https://doi.org/10.1038/s41467-022-30805-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Most genetic studies of autism spectrum disorder (ASD) have focused on the nuclear genome. Here, the authors show that variations in mitochondrial DNA, detectable at birth, are also associated with risk of ASD.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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