Infection and Drug Resistance (Dec 2021)
Development and Research Progress of Anti-Drug Resistant Bacteria Drugs
Abstract
Xiangyi Cui,1 Yuhong Lü,1,2 Changwu Yue1,2 1Key Laboratory of Microbial Drugs Innovation and Transformation of Yan’an, School of Basic Medicine, Yan’an University, Yan’an, 716000, Shaanxi, People’s Republic of China; 2Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources, Yan’an University, Yan’an, 716000, Shaanxi, People’s Republic of ChinaCorrespondence: Yuhong Lü; Changwu YueYan’an University, No. 580 Shengdi Road, Baota District, Yan’an, 716000, Shaanxi, People’s Republic of ChinaTel/Fax +86 911-2332-067Email [email protected]; [email protected]: Bacterial resistance has become increasingly serious because of the widespread use and abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a serious threat to human public health and attracted the attention of the World Health Organization (WHO) and the governments of various countries. Therefore, the establishment of measures against bacterial resistance and the discovery of new antibacterial drugs are increasingly urgent to better contain the emergence of bacterial resistance and provide a reference for the development of new antibacterial drugs. In this review, we discuss some antibiotic drugs that have been approved for clinical use and a partial summary of the meaningful research results of anti-drug resistant bacterial drugs in different fields, including the antibiotic drugs approved by the FDA from 2015 to 2020, the potential drugs against drug-resistant bacteria, the new molecules synthesized by chemical modification, combination therapy, drug repurposing, immunotherapy and other therapies.Keywords: multidrug-resistant bacteria, antimicrobial resistance, novel antibiotics, antibiotics, antibiotic discovery
