Nature Communications (Oct 2018)
Defective transcription elongation in a subset of cancers confers immunotherapy resistance
- Vishnu Modur,
- Navneet Singh,
- Vakul Mohanty,
- Eunah Chung,
- Belal Muhammad,
- Kwangmin Choi,
- Xiaoting Chen,
- Kashish Chetal,
- Nancy Ratner,
- Nathan Salomonis,
- Matthew T. Weirauch,
- Susan Waltz,
- Gang Huang,
- Lisa Privette-Vinnedge,
- Joo-Seop Park,
- Edith M. Janssen,
- Kakajan Komurov
Affiliations
- Vishnu Modur
- Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center (CCHMC)
- Navneet Singh
- Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center (CCHMC)
- Vakul Mohanty
- University of Cincinnati Graduate Program in Systems Biology and Physiology
- Eunah Chung
- Division of Developmental Biology, CCHMC
- Belal Muhammad
- Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center (CCHMC)
- Kwangmin Choi
- Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center (CCHMC)
- Xiaoting Chen
- Center for Autoimmune Genomics and Etiology, CCHMC
- Kashish Chetal
- Division of Biomedical Informatics, CCHMC
- Nancy Ratner
- Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center (CCHMC)
- Nathan Salomonis
- Division of Biomedical Informatics, CCHMC
- Matthew T. Weirauch
- Division of Developmental Biology, CCHMC
- Susan Waltz
- Departments of Cancer Biology and Research Service, University of Cincinnati and Cincinnati Veteran’s Hospital Medical Center
- Gang Huang
- Division of Pathology, CCHMC
- Lisa Privette-Vinnedge
- Division of Oncology, CCHMC
- Joo-Seop Park
- Division of Developmental Biology, CCHMC
- Edith M. Janssen
- Division of Immunobiology, CCHMC
- Kakajan Komurov
- Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center (CCHMC)
- DOI
- https://doi.org/10.1038/s41467-018-06810-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TEdeff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as potential routes for immune resistance.
