The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis

Mohamed Osama Ali Abdalla; Tatsuro Yamamoto; Kazumitsu Maehara; Jumpei Nogami; Yasuyuki Ohkawa; Hisashi Miura; Rawin Poonperm; Ichiro Hiratani; Hideki Nakayama; Mitsuyoshi Nakao; Noriko Saitoh

doi:10.1038/s41467-019-11378-4

Nature Communications (Aug 2019)

The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis

Mohamed Osama Ali Abdalla,
Tatsuro Yamamoto,
Kazumitsu Maehara,
Jumpei Nogami,
Yasuyuki Ohkawa,
Hisashi Miura,
Rawin Poonperm,
Ichiro Hiratani,
Hideki Nakayama,
Mitsuyoshi Nakao,
Noriko Saitoh

Affiliations

Mohamed Osama Ali Abdalla: Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University
Tatsuro Yamamoto: Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University
Kazumitsu Maehara: Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
Jumpei Nogami: Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
Yasuyuki Ohkawa: Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
Hisashi Miura: Laboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR)
Rawin Poonperm: Laboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR)
Ichiro Hiratani: Laboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR)
Hideki Nakayama: Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University
Mitsuyoshi Nakao: Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University
Noriko Saitoh: Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University

DOI: https://doi.org/10.1038/s41467-019-11378-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Long term estrogen deprivation can result in apoptosis in breast cancer cells. Here, the authors show that this apoptosis is induced by the long-range chromatin interaction of loci containing the ESR1 and FOXO 3 genes, resulting in FOXO 3-mediated apoptosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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