Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells

Vincent Geoghegan; Kirsty Stainton; Stephanie M. Rainey; Thomas H. Ant; Adam A. Dowle; Tony Larson; Svenja Hester; Philip D. Charles; Benjamin Thomas; Steven P. Sinkins

doi:10.1038/s41467-017-00610-8

Nature Communications (Sep 2017)

Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells

Vincent Geoghegan,
Kirsty Stainton,
Stephanie M. Rainey,
Thomas H. Ant,
Adam A. Dowle,
Tony Larson,
Svenja Hester,
Philip D. Charles,
Benjamin Thomas,
Steven P. Sinkins

Affiliations

Vincent Geoghegan: MRC-University of Glasgow Centre for Virus Research, University of Glasgow
Kirsty Stainton: Biomedical and Life Sciences, University of Lancaster
Stephanie M. Rainey: MRC-University of Glasgow Centre for Virus Research, University of Glasgow
Thomas H. Ant: MRC-University of Glasgow Centre for Virus Research, University of Glasgow
Adam A. Dowle: Bioscience Technology Facility, Department of Biology, University of York
Tony Larson: Bioscience Technology Facility, Department of Biology, University of York
Svenja Hester: Sir William Dunn School of Pathology, University of Oxford
Philip D. Charles: Sir William Dunn School of Pathology, University of Oxford
Benjamin Thomas: Sir William Dunn School of Pathology, University of Oxford
Steven P. Sinkins: MRC-University of Glasgow Centre for Virus Research, University of Glasgow

DOI: https://doi.org/10.1038/s41467-017-00610-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Wolbachia infection of mosquitoes can block dengue virus infection and is tested in field trials, but the mechanism of action is unclear. Using proteomics, Geoghegan et al. here identify effects of Wolbachia on cholesterol homeostasis and dengue virus replication in Aedes aegypti.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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