Communications Medicine (Oct 2021)

Genetic and phenotypic analysis of the causal relationship between aging and COVID-19

  • Kejun Ying,
  • Ranran Zhai,
  • Timothy V. Pyrkov,
  • Anastasia V. Shindyapina,
  • Marco Mariotti,
  • Peter O. Fedichev,
  • Xia Shen,
  • Vadim N. Gladyshev

DOI
https://doi.org/10.1038/s43856-021-00033-z
Journal volume & issue
Vol. 1, no. 1
pp. 1 – 15

Abstract

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Ying et al. conduct a multi-instrument Mendelian randomization study looking at the link between aging and COVID-19 risk. They observe an association between genetic variation implicated in longevity and decreased risk of COVID-19 infection and hospitalization, with Notch signaling and immune system development loci found to be important in aging-related COVID-19 risk.