Lidocaine’s Ineffectiveness in Mitigating Lipopolysaccharide-Induced Pain and Peristaltic Effects in Horses
Lara Nunes Sousa,
Isabella Caixeta Winter,
Diego Duarte Varela,
Eduarda Zancanaro Luvison,
Juan Felipe Colmenares Guzmán,
Ana Moutinho Vilella Machado,
Renata Diniz Vilela Figueiredo,
Gabriel Tavares Pena,
Ana Clara Silva dos Santos,
Rafael Resende Faleiros,
Armando de Mattos Carvalho
Affiliations
Lara Nunes Sousa
EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
Isabella Caixeta Winter
EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
Diego Duarte Varela
EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
Eduarda Zancanaro Luvison
EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
Juan Felipe Colmenares Guzmán
Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
Ana Moutinho Vilella Machado
Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
Renata Diniz Vilela Figueiredo
Veterinary Medicine, Pontifical Catholic University of Minas Gerais, Belo Horizonte 30140-002, Brazil
Gabriel Tavares Pena
Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
Ana Clara Silva dos Santos
Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
Rafael Resende Faleiros
EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
Armando de Mattos Carvalho
EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil
The present study involved seven horses in a randomized crossover clinical trial to evaluate the effect of lidocaine on horses with induced endotoxemia. Horses received intravenous lidocaine (1.5 mg/kg bolus, followed by 0.05 mg/kg bwt/min) or placebo (0.9% sodium chloride at the same manner) one hour before LPS administration (0.03 μg/kg, IV infusion over 30 min). We monitored clinic and hematologic parameters, abdominal auscultation, ultrasound, and pain over time. No relevant clinical differences existed between treatments regarding peristalsis, abdominal pain, or any other parameters before and after endotoxemia induction. These findings do not support the clinical use of lidocaine to mitigate abdominal pain and intestinal hypomotility promoted by endotoxemia in horses.
