Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells

Ilaria Frasson; Paola Soldà; Matteo Nadai; Sara Lago; Sara N. Richter

doi:10.1038/s42003-021-02035-y

Communications Biology (Apr 2021)

Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells

Ilaria Frasson,
Paola Soldà,
Matteo Nadai,
Sara Lago,
Sara N. Richter

Affiliations

Ilaria Frasson: Department of Molecular Medicine, University of Padua
Paola Soldà: Department of Molecular Medicine, University of Padua
Matteo Nadai: Department of Molecular Medicine, University of Padua
Sara Lago: Department of Molecular Medicine, University of Padua
Sara N. Richter: Department of Molecular Medicine, University of Padua

DOI: https://doi.org/10.1038/s42003-021-02035-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Ilaria Frasson et al. find that the herpesvirus major transcription factor ICP4 regulates viral gene expression and replication through binding to parallel DNA G-quadruplexes (G4s). These results suggest that drugs targeting G4s at ICP4-regulated gene promoters could be an effective antiviral strategy.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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