Communications Biology (Dec 2022)

Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease

  • Moustafa Algamal,
  • Alyssa N. Russ,
  • Morgan R. Miller,
  • Steven S. Hou,
  • Megi Maci,
  • Leon P. Munting,
  • Qiuchen Zhao,
  • Dmitry Gerashchenko,
  • Brian J. Bacskai,
  • Ksenia V. Kastanenka

DOI
https://doi.org/10.1038/s42003-022-04268-x
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 9

Abstract

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Interneuron-specific lines reveal that somatostatin interneurons are hyperactive whereas pyramidal neurons and PV interneurons are ‘hypoactive’ in the APP/PS1 mouse model of Alzheimer’s Disease.