Nature Communications (Mar 2021)
FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
- Sébastien Relier,
- Julie Ripoll,
- Hélène Guillorit,
- Amandine Amalric,
- Cyrinne Achour,
- Florence Boissière,
- Jérôme Vialaret,
- Aurore Attina,
- Françoise Debart,
- Armelle Choquet,
- Françoise Macari,
- Virginie Marchand,
- Yuri Motorin,
- Emmanuelle Samalin,
- Jean-Jacques Vasseur,
- Julie Pannequin,
- Francesca Aguilo,
- Evelyne Lopez-Crapez,
- Christophe Hirtz,
- Eric Rivals,
- Amandine Bastide,
- Alexandre David
Affiliations
- Sébastien Relier
- IGF, Univ. Montpellier, CNRS, INSERM
- Julie Ripoll
- LIRMM, Univ. Montpellier, CNRS
- Hélène Guillorit
- IGF, Univ. Montpellier, CNRS, INSERM
- Amandine Amalric
- IGF, Univ. Montpellier, CNRS, INSERM
- Cyrinne Achour
- Wallenberg Centre for Molecular Medicine (WCMM), Umea University
- Florence Boissière
- ICM
- Jérôme Vialaret
- IRMB-PPC, Univ. Montpellier, INSERM, CHU Montpellier, CNRS
- Aurore Attina
- IRMB-PPC, Univ. Montpellier, INSERM, CHU Montpellier, CNRS
- Françoise Debart
- IBMM, CNRS, Univ. Montpellier, ENSCM
- Armelle Choquet
- IGF, Univ. Montpellier, CNRS, INSERM
- Françoise Macari
- IGF, Univ. Montpellier, CNRS, INSERM
- Virginie Marchand
- Université de Lorraine, IMoPA UMR7365 CNRS-UL and UMS2008/US40 IBSLor, UL-CNRS-INSERM, BioPole
- Yuri Motorin
- Université de Lorraine, IMoPA UMR7365 CNRS-UL and UMS2008/US40 IBSLor, UL-CNRS-INSERM, BioPole
- Emmanuelle Samalin
- IGF, Univ. Montpellier, CNRS, INSERM
- Jean-Jacques Vasseur
- IBMM, CNRS, Univ. Montpellier, ENSCM
- Julie Pannequin
- IGF, Univ. Montpellier, CNRS, INSERM
- Francesca Aguilo
- Wallenberg Centre for Molecular Medicine (WCMM), Umea University
- Evelyne Lopez-Crapez
- ICM
- Christophe Hirtz
- IRMB-PPC, Univ. Montpellier, INSERM, CHU Montpellier, CNRS
- Eric Rivals
- LIRMM, Univ. Montpellier, CNRS
- Amandine Bastide
- IGF, Univ. Montpellier, CNRS, INSERM
- Alexandre David
- IGF, Univ. Montpellier, CNRS, INSERM
- DOI
- https://doi.org/10.1038/s41467-021-21758-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am demethylase activity, not through internal m6A demethylase activity.
