L-4, a Well-Tolerated and Orally Active Inhibitor of Hedgehog Pathway, Exhibited Potent Anti-tumor Effects Against Medulloblastoma in vitro and in vivo

• Mingfei Zhu,
• Hong Wang,
• Chenglin Wang,
• Yanfen Fang,
• Tong Zhu,
• Weili Zhao,
• Xiaochun Dong,
• Xiongwen Zhang

Affiliations

Mingfei Zhu

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

Hong Wang

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

Chenglin Wang

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, China

Yanfen Fang

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

Tong Zhu

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

Weili Zhao

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, China

Xiaochun Dong

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, China

Xiongwen Zhang

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China