Anti-selective [3+2] (Hetero)annulation of non-conjugated alkenes via directed nucleopalladation

Abstract

Dihydrobenzofurans and indolines are common substructures in medicines and natural products. Herein, the authors report a palladium-catalyzed [3 + 2] (hetero)annulation proceeding in an anti-selective fashion and enabling direct access to these valuable heterocycles with broad reaction scope.