Interactions between comorbidity and treatment of chronic lymphocytic leukemia: results of German Chronic Lymphocytic Leukemia Study Group trials

Valentin Goede; Paula Cramer; Raymonde Busch; Manuela Bergmann; Martina Stauch; Georg Hopfinger; Stephan Stilgenbauer; Hartmut Döhner; Anne Westermann; Clemens M. Wendtner; Barbara Eichhorst; Michael Hallek

doi:10.3324/haematol.2013.096792

Haematologica (Jun 2014)

Interactions between comorbidity and treatment of chronic lymphocytic leukemia: results of German Chronic Lymphocytic Leukemia Study Group trials

Valentin Goede,
Paula Cramer,
Raymonde Busch,
Manuela Bergmann,
Martina Stauch,
Georg Hopfinger,
Stephan Stilgenbauer,
Hartmut Döhner,
Anne Westermann,
Clemens M. Wendtner,
Barbara Eichhorst,
Michael Hallek

Affiliations

Valentin Goede: Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, Germany;Department of Geriatric Medicine and Research, St. Marien Hospital and University of Cologne, Germany
Paula Cramer: Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, Germany
Raymonde Busch: Institute of Medical Statistics and Epidemiology, Technical University of Munich, Germany
Manuela Bergmann: Department of Internal Medicine III, University of Ulm, Germany
Martina Stauch: Private practice, Kronach, Germany
Georg Hopfinger: Medical Department III, Paracelsus Medical University Salzburg, Austria
Stephan Stilgenbauer: Department of Internal Medicine III, University of Ulm, Germany
Hartmut Döhner: Department of Internal Medicine III, University of Ulm, Germany
Anne Westermann: Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, Germany
Clemens M. Wendtner: Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, Germany;Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, Schwabing Hospital, Munich, Germany
Barbara Eichhorst: Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, Germany
Michael Hallek: Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University of Cologne, Germany;Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Germany

DOI: https://doi.org/10.3324/haematol.2013.096792
Journal volume & issue: Vol. 99, no. 6

Abstract

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This study investigated the impact of comorbidity in 555 patients with chronic lymphocytic leukemia enrolled in two trials of the German Chronic Lymphocytic Leukemia Study Group on first-line treatment with fludarabine plus cyclophosphamide, fludarabine, or chlorambucil. Patients with two or more comorbidities and patients with less than two comorbidities differed in overall survival (71.7 versus 90.2 months; P

Published in Haematologica

ISSN: 0390-6078 (Print); 1592-8721 (Online)
Publisher: Ferrata Storti Foundation
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://www.haematologica.org

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