Nature Communications (Apr 2016)
Nuclear RNA-seq of single neurons reveals molecular signatures of activation
- Benjamin Lacar,
- Sara B. Linker,
- Baptiste N. Jaeger,
- Suguna Rani Krishnaswami,
- Jerika J. Barron,
- Martijn J. E. Kelder,
- Sarah L. Parylak,
- Apuã C. M. Paquola,
- Pratap Venepally,
- Mark Novotny,
- Carolyn O'Connor,
- Conor Fitzpatrick,
- Jennifer A. Erwin,
- Jonathan Y. Hsu,
- David Husband,
- Michael J. McConnell,
- Roger Lasken,
- Fred H. Gage
Affiliations
- Benjamin Lacar
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Sara B. Linker
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Baptiste N. Jaeger
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Suguna Rani Krishnaswami
- J. Craig Venter Institute
- Jerika J. Barron
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Martijn J. E. Kelder
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Sarah L. Parylak
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Apuã C. M. Paquola
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Pratap Venepally
- J. Craig Venter Institute
- Mark Novotny
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Carolyn O'Connor
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Conor Fitzpatrick
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Jennifer A. Erwin
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Jonathan Y. Hsu
- Laboratory of Genetics, The Salk Institute for Biological Studies
- David Husband
- Laboratory of Genetics, The Salk Institute for Biological Studies
- Michael J. McConnell
- Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
- Roger Lasken
- J. Craig Venter Institute
- Fred H. Gage
- Laboratory of Genetics, The Salk Institute for Biological Studies
- DOI
- https://doi.org/10.1038/ncomms11022
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
The molecular dynamics associated with neuronal activation patterns in vivo are unclear. Lacar et al. perform single-nuclei RNA-sequencing of hippocampal neurons from mice exposed to a novel environment, and identify large-scale transcriptome changes in individual neurons associated with the experience.
