Genetic fusions favor tumorigenesis through degron loss in oncogenes

Jing Liu; Collin Tokheim; Jonathan D. Lee; Wenjian Gan; Brian J. North; X. Shirley Liu; Pier Paolo Pandolfi; Wenyi Wei

doi:10.1038/s41467-021-26871-y

Nature Communications (Nov 2021)

Genetic fusions favor tumorigenesis through degron loss in oncogenes

Jing Liu,
Collin Tokheim,
Jonathan D. Lee,
Wenjian Gan,
Brian J. North,
X. Shirley Liu,
Pier Paolo Pandolfi,
Wenyi Wei

Affiliations

Jing Liu: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Collin Tokheim: Department of Data Science, Dana-Farber Cancer Institute
Jonathan D. Lee: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Wenjian Gan: Department of Biochemistry and Molecular Biology, Medical University of South Carolina
Brian J. North: Department of Biomedical Sciences, Creighton University
X. Shirley Liu: Department of Data Science, Dana-Farber Cancer Institute
Pier Paolo Pandolfi: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Wenyi Wei: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-021-26871-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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The impact of genetic fusions on degrons, which are motifs for ubiquitin-mediated protein degradation, has not been fully explored. Here, the authors analyse fusion genes affecting degrons in pan-cancer genomics data, validate their functional impact and find enrichment for both internal and C-terminal degron losses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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