To compare the effectiveness of density gradient centrifugation and swim-up wash semen preparation technique on the clinical outcome in intrauterine insemination

Abstract

OBJECTIVE: To compare the effectiveness of DGC and swim-up wash semen preparation technique on the clinical outcome in sub fertile couple who underwent intrauterine insemination. DESIGN: It is a prospective study of 100 sub fertile couples undergoing 200 cycles of assisted conception using IUI. RESULTS: Seventeen pregnancies out of fifty nine pregnancies (28.81%) resulted in live birth with DGC method as compared to twelve pregnancies out of fifty nine(2034%) resulted in live birth with swim-up method. The pregnancy rate for DGC method was 31% and for swim-up method was 28%.The miscarriage rate for DGC method 16.95% and for swim-up method 6.78%. The incidence of multiple pregnancy rate in DGC method was nil and in swim-up group was 6.78%. The incidence of ectopic pregnancy in DGC method was nil and for swim-up group was 6.78%. CONCLUSION: DGC method of sperm preparation has better outcome in terms of live birth rate and pregnancy rate in couples who have been subjected to IUI treatment. However there is higher multiple pregnancy rate and ectopic pregnancy rate swim-up method of sperm preparation.

Keywords

• IUI
• Swim-up Wash
• Density Gradient Centrifugation
• Pregnancy