Frontiers in Oncology (Dec 2022)

The cause analysis of benign uretero-ileal anastomotic stricture after radical cystectomy and urinary diversion

  • Zhenghong Liu,
  • Bin Zheng,
  • Yuqi Hu,
  • Haichang Li,
  • Xiaowen Qin,
  • Xuanhan Hu,
  • Shuai Wang,
  • Heng Wang,
  • Pu Zhang,
  • Qijun Wo,
  • Li Sun,
  • Yixuan Mou,
  • Feng Liu,
  • Jianxin Cui,
  • Dahong Zhang

DOI
https://doi.org/10.3389/fonc.2022.1070141
Journal volume & issue
Vol. 12

Abstract

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BackgroundBenign uretero-ileal anastomotic stricture (UIAS) is a major complication following radical cystectomy (RC) and ileal orthotopic bladder substitution, and it can occur in combination with other complications. But risk factors for patients with UIAS have not been well described.Material and methodsWe retrospectively reviewed 198 patients treated with RC for bladder cancer from 2014 to 2019 at the Zhejiang Provincial People’s Hospital. Patient demographic and clinical variables were examined to determine the risk factors associated with UIAS by univariate and multivariate logistic regression analysis.ResultsA total of 180 patients into the group standards and in all 360 uretero-ileal anastomoses. Among the above cases, 22 patients developed UIAS, including 10 cases of left UIAS, nine cases of right UIAS, and three cases of bilateral UIAS. There was no difference in demographic, operative, or perioperative variables between patients with and without UIAS. In a multivariate analysis, after adjusting for gender, age, surgical methods, and underlying diseases, intraoperative or postoperative blood transfusion (HR = 0.144, P <0.01), postoperative urinary tract infection (HR = 3.624, P <0.01), and extracorporeal bladder anastomosis (HR = 3.395, P = 0.02) significantly increased the risk of UIAS.ConclusionsIn our experience, intraoperative or postoperative blood transfusion, postoperative urinary tract infection, and extracorporeal neobladder anastomoses increased the risk of UIAS after radical cystectomy and ileal orthotopic bladder substitution surgery. Further studies with larger samples are necessary to validate this result.

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