The Association of Angiotension Converting Enzyme Gene Polimorphism with Prognosis of Henoch-Schönlein Purpura with Renal Involvement in the Children

Abstract

Aim:Henoch-Schönlein purpura (HSP) is a vasculitis rarely progresses to renal failure. The mechanism of renal failure in HSP has been associated with increased angiotensin converting enzyme (ACE) activity and increased local angiotension-II concentration as a result of deletion in ACE gene. Here relation between ACE gene polymorphism and prognosis of HSP nephritis was investigated.Materials and Methods:Forty-two children with HSP nephritis and ACE gene polymorphism studied were included in the study. Those who have deletion (DD) allele (Group-1) and heterozygous deletion (ID) or insertion (II) allele (Group-2)) compared according to their demographic characteristic, severity of renal involvement.Results:Between two groups, there was no statically difference in the terms of age, gender distribution and duration of follow-up (p=0,347, p=422, p=0,267). In group-1, 11 cases had mild, 14 had moderate, 4 had severe renal involvement. In group-2 4 cases had mild, 8 had moderate and 1 had severe renal involvement. There was no statistically significant difference in severity of renal involvement between two groups (p=0,375). Although there was a difference in proteinuria recovery rates between the two groups, the number of cases was not enough for statistical analysis (p=0,127) [ID or II / ID (OR): 3,667, (95% Cl 0.619-21.739).Conclusion:There was no significant association between the severity of renal involvement of HSP with DD genotype or D allele, however, this needs to be supported by studies with larger series.

Keywords

• ace gene polymorphism
• nephritis
• henoch-schönlein purpura