Dataset for homologous proteins in Drosophila melanogaster for SARS-CoV-2/human interactome
Mushtaq Hussain,
Nusrat Jabeen,
Sanya Shabbir,
Nasir Udin,
Basma Aziz,
Anusha Amanullah,
Fozia Raza,
Ayesha Ashraf Baig
Affiliations
Mushtaq Hussain
Bioinformatics and Molecular Medicine Research Group, Dow Research Institute of Bitoechnology and Biomedical Sciences, Dow College of Biotechnology, Dow University of Health Sciences, Karachi, Pakistan; Corresponding author.
Nusrat Jabeen
Department of Microbiology, University of Karachi, Karachi, Pakistan
Sanya Shabbir
Bioinformatics and Molecular Medicine Research Group, Dow Research Institute of Bitoechnology and Biomedical Sciences, Dow College of Biotechnology, Dow University of Health Sciences, Karachi, Pakistan; Department of Microbiology, University of Karachi, Karachi, Pakistan
Nasir Udin
Faculty of Computer Science, IBA, Karachi, Pakistan
Basma Aziz
Bioinformatics and Molecular Medicine Research Group, Dow Research Institute of Bitoechnology and Biomedical Sciences, Dow College of Biotechnology, Dow University of Health Sciences, Karachi, Pakistan
Anusha Amanullah
Bioinformatics and Molecular Medicine Research Group, Dow Research Institute of Bitoechnology and Biomedical Sciences, Dow College of Biotechnology, Dow University of Health Sciences, Karachi, Pakistan
Fozia Raza
Bioinformatics and Molecular Medicine Research Group, Dow Research Institute of Bitoechnology and Biomedical Sciences, Dow College of Biotechnology, Dow University of Health Sciences, Karachi, Pakistan
Ayesha Ashraf Baig
Bioinformatics and Molecular Medicine Research Group, Dow Research Institute of Bitoechnology and Biomedical Sciences, Dow College of Biotechnology, Dow University of Health Sciences, Karachi, Pakistan
Animal modelling for infectious diseases is critical to understand the biology of the pathogens including viruses and to develop therapeutic strategies against it. Herein, we present the sequence homology and expression data analysis of proteins found in Drosophila melanogaster that are orthologous to human proteins, reported as components of SARS-CoV-2/Human interactome. The dataset enlists sequence homology, query coverage, domain conservation, OrthoMCL and Ensembl Genome Browser support of 326 proteins in D.melanogaster that are potentially orthologous to 417 human proteins reported for their direct physical interactions with 28 proteins encoded by SARS-CoV-2 genome. Expression of these D.melanogaster orthologous genes in 26 anatomical positions are also plotted as heat maps in 27 sets, corresponding to the potential protein interactors for each viral protein. The data could be used to direct experiments and potentially predict their phenotypic and molecular outcome in order to dissect the biological roles and molecular functionality of SARS-CoV-2 proteins in a convenient animal model system like D.melanogaster.
