INFLUENCE OF NEONATAL SCREENING FOR CYSTIC FIBROSIS BY THE EXAMPLE OF PATIENTS OF THE MOSCOW REGION

Abstract

Study objective: comparative evaluation of clinical status of patients with cystic fibrosis (CF) 6–9 years, the diagnosis of which was established before the start of neonatal screening (NS) for MV in the Moscow region and in same age group since the start of the NS according to the register 2012 and 2015. Patients and methods. The patients were divided into 2 groups: I – 45 children aged 6–9 years, diagnosed before the beginning of the NS, II – 86 children aged 6–9 years, identified after the start of the NS. Results. A comparative assessment of the age of diagnosis had a significant difference between groups I and II. The average age of diagnosis in group I was 2.29 (±2.29) years, in group II the average age of diagnosis – 0.66 (± 1.13) years (p = 0.0000). According to the microbiological status diagnosed according to the NS program (group II), chronic infection of the respiratory tract by Ps. aeruginosa was less frequent in this group (37.78% of patients in group I vs. 14,10 % in group II) (p = 0.0026). In the group of patients identified by the newborns screening program directed at newborns (group II) a statistically significant decrease of the ongoing intravenous (p = 0.0000) and inhaled antibiotic therapy (p = 0.0139) and reduced compared with group I patients receiving bronchodilators (p = 0.0322). Conclusion. A positive impact of neonatal screening for MV at the age of diagnosis and a number of important indicators of the disease was demonstrated.

Keywords

• cystic fibrosis
• neonatal screening
• sweat test