Nature Communications (Nov 2018)

NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

  • Jean-Philippe Brosseau,
  • Chung-Ping Liao,
  • Yong Wang,
  • Vijay Ramani,
  • Travis Vandergriff,
  • Michelle Lee,
  • Amisha Patel,
  • Kiyoshi Ariizumi,
  • Lu Q. Le

DOI
https://doi.org/10.1038/s41467-018-07452-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Germline mono-allelic loss of the tumour suppressor NF1 predisposes patients to the development of benign lesions but rarely further progression into cancer development. Here the authors use mouse models to show that an NF1 heterozygous microenvironment accelerates the formation of benign tumours but impairs progression to malignancy.