Protein kinase A modulation of CaV1.4 calcium channels

Lingjie Sang; Ivy E. Dick; David T. Yue

doi:10.1038/ncomms12239

Nature Communications (Jul 2016)

Protein kinase A modulation of CaV1.4 calcium channels

Lingjie Sang,
Ivy E. Dick,
David T. Yue

Affiliations

Lingjie Sang: Department of Biomedical Engineering, Calcium Signals Laboratory, The Johns Hopkins University School of Medicine
Ivy E. Dick: Department of Biomedical Engineering, Calcium Signals Laboratory, The Johns Hopkins University School of Medicine
David T. Yue: Department of Biomedical Engineering, Calcium Signals Laboratory, The Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/ncomms12239
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Phosphorylation of L-type calcium CaV channels by protein kinase A is essential for several physiological events. Here, the authors show how this kinase regulates CaV1.4 activity, suggesting a general regulatory mechanism for all L-type calcium channels.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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