NUT Midline Carcinoma at the Anterior Skull Base - A Case Report

Abstract

An uncommon and severe form of human malignancy is called NUT midline carcinoma (NMC). The mediastinum or midline of the upper aerodigestive tract contains the majority of NMCs. A chromosomal rearrangement affecting the NUT gene, which produces oncoproteins regarded as a major pathogenic driver of cellular transformation, is the genetic cause of NMC. When a commercial antibody against NUT is available, NMC can be diagnosed, and the diagnosis is confirmed by positive nuclear immunohistochemistry staining. There is no standard treatment for NMC to date. There may be a multimodal approach for NMC such as chemotherapy, surgical intervention, and radiotherapy adopted currently in clinical practice. Despite aggressive radiation therapy and chemotherapy, the typical survival is less than 1 year. The majority of cases with NMC die due to local complications of the tumor or complications due to treatment. Here, we are presenting a case of NMC in young adults with isolated involvement of the anterior skull base with bony erosion and intracranial extension.

Keywords

• anterior skull base
• chemoradiation
• nasal cavity
• nut midline carcinoma