Frontiers in Nutrition (May 2022)
Poor Pre-operative Nutritional Status Is a Risk Factor of Post-operative Infections in Patients With Gastrointestinal Cancer—A Multicenter Prospective Cohort Study
- Li Zhang,
- Siwen Wang,
- Xuejin Gao,
- Tingting Gao,
- Lingli Huang,
- Bo Lian,
- Yingchao Gu,
- Jianjiao Chen,
- Dong Guo,
- Zhenyi Jia,
- Yong Wang,
- Fangyou Gong,
- Junde Zhou,
- Zhigang Xue,
- Zhida Chen,
- Jielian Xu,
- Leilei Wang,
- Jun Qian,
- Guifang Deng,
- Hao Hu,
- Yao Nie,
- Gang Li,
- Mengbin Li,
- Hua Yang,
- Wei Zhao,
- Yanbing Zhou,
- Huanlong Qin,
- Xiaoting Wu,
- Kunhua Wang,
- Qiang Chi,
- Jianchun Yu,
- Yun Tang,
- Pianhong Zhang,
- Gang Jin,
- Bin Ouyang,
- Guoli Li,
- Dong Hang,
- Xinying Wang,
- Xinying Wang
Affiliations
- Li Zhang
- Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
- Siwen Wang
- Department of General Surgery, Jinling Hospital, Southern Medical University, Nanjing, China
- Xuejin Gao
- Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
- Tingting Gao
- Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
- Lingli Huang
- Department of General Surgery, Cancer Institute of Jiangsu Province, Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China
- Bo Lian
- Department of Gastrointestinal Surgery, The First Affiliated Hospital of Air Force Medical University, Xi'an, China
- Yingchao Gu
- Department of General Surgery, The Second Affiliated Hospital, Army Medical University, Chongqing, China
- Jianjiao Chen
- Department of General Surgery, Northern Jiangsu Province People's Hospital, Yangzhou, China
- Dong Guo
- Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China
- Zhenyi Jia
- Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China
- Yong Wang
- Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
- Fangyou Gong
- 0Department of General Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, China
- Junde Zhou
- 1Department of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Ha'erbin, China
- Zhigang Xue
- 2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
- Zhida Chen
- 3Department of General Surgery, First Medical Center of Chinese PLA General Hospital, Beijing, China
- Jielian Xu
- 4Department of Clinical Nutrition, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
- Leilei Wang
- 5Department of Clinical Nutrition, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Jun Qian
- 6Department of Gastrointestinal Surgery, Changzhou Second People's Hospital, Nanjing Medical University, Changzhou, China
- Guifang Deng
- 7Department of Clinical Nutrition, Union Shenzhen Hospital of Huazhong University of Science and Technology, Shenzhen, China
- Hao Hu
- 8Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, China
- Yao Nie
- 9Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Gang Li
- Department of General Surgery, Cancer Institute of Jiangsu Province, Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China
- Mengbin Li
- Department of Gastrointestinal Surgery, The First Affiliated Hospital of Air Force Medical University, Xi'an, China
- Hua Yang
- Department of General Surgery, The Second Affiliated Hospital, Army Medical University, Chongqing, China
- Wei Zhao
- Department of General Surgery, Northern Jiangsu Province People's Hospital, Yangzhou, China
- Yanbing Zhou
- Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China
- Huanlong Qin
- Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China
- Xiaoting Wu
- Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
- Kunhua Wang
- 0Department of General Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, China
- Qiang Chi
- 1Department of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Ha'erbin, China
- Jianchun Yu
- 2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
- Yun Tang
- 3Department of General Surgery, First Medical Center of Chinese PLA General Hospital, Beijing, China
- Pianhong Zhang
- 5Department of Clinical Nutrition, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Gang Jin
- 8Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, China
- Bin Ouyang
- 9Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- Guoli Li
- Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
- Dong Hang
- 0Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Department of Epidemiology, Nanjing Medical University, Nanjing, China
- Xinying Wang
- Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
- Xinying Wang
- Department of General Surgery, Jinling Hospital, Southern Medical University, Nanjing, China
- DOI
- https://doi.org/10.3389/fnut.2022.850063
- Journal volume & issue
-
Vol. 9
Abstract
ObjectiveThis study aimed to assess the prognostic value of the Nutritional Risk Score 2002 (NRS2002) and patient-generated subjective global assessment (PG-SGA) for post-operative infections in patients with gastric cancer (GC) and colorectal cancer (CRC) who underwent curative surgery.MethodsThis prospective study included 1,493 GC patients and 879 CRC patients who underwent curative surgery at 18 hospitals in China between April 2017 and March 2020. The NRS2002 and PG-SGA were performed on the day of admission. The relationship between the nutritional status of patients before surgery and post-surgical incidence of infection was analyzed using univariate and multiple logistic regression analyses.ResultsAccording to NRS2002, the prevalence of nutritional risk was 51.1% in GC patients and 63.9% in CRC patients. According to the PG-SGA, 38.9% of GC patients and 54.2% of CRC patients had malnutrition. Approximately 4.4% of the GC patients and 9.9% of the CRC patients developed infectious complications after surgery. The univariate and multiple logistic regression analyses showed that the risk of infections was significantly higher in GC patients with a high nutritional risk score (NRS2002 ≥5) than in those with a low score (NRS2002 <3), and the PG-SGA score was identified as a predictor of post-operative infection complications of CRC.ConclusionThe pre-operative nutritional status of patients with GC or CRC has an impact on post-operative infection occurrence. NRS2002 ≥5 was a risk factor for post-operative infection in patients with GC, and the PG-SGA B/C was a predictor of infections in patients with CRC.
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