The impact of using probiotics on metabolic disorders of women with polycystic ovary syndrome

Abstract

Introduction: Polycystic ovary syndrome is a common endocrine and metabolic disorder affecting women of reproductive age. The course is primarily associated with menstrual disorders, obesity, insulin resistance and hyperandrogenism. The gut microbiota dysbiosis theory (DOGMA), established in 2012, suggests a link between the composition of gut bacteria and the development of metabolic disorders. Other studies confirm this relationship. This article analyzes the effect of probiotic supplementation on the alteration of gut microbial flora and the course of PCOS. Aim of the study: Aim of our study was to review the available studies on the effect of probiotic use on the course of polycystic ovary syndrome. We considered the influence of supplementation on body weight, insulin resistance and lipid profile of the women studied. Methods and materials: This article is based on the literature found in PubMed Database with use of keywords such as “PCOS”; „polycystic ovary syndrome”; “probiotics”; „gut microbiota”; „gut microbiome”. Results: The collective results of the reviewed literature indicate that probiotics may have a beneficial effect on the course of polycystic ovary syndrome. In a number of studies, their supplementation resulted in a decrease in weight, insulin, triglycerides and VLDL cholesterol. For fasting glucose, HOMAR-IR, total cholesterol and LDL fraction, the results were inconclusive. Conclusion: Probiotics may have a positive effect on metabolic disorders in women with PCOS, but more research is needed to confirm the good effects of their use in treatment.

Keywords

• polycystic ovary syndrome
• PCOS
• probiotics
• gut microbiota
• gut microbiome