miR-145-5p suppresses cell proliferation by targeting IGF1R and NRAS genes in multiple myeloma cells

Kaya Murat; Suer Ilknur; Ozgur Emre; Capik Ozel; Karatas Omer Faruk; Ozturk Sukru; Gezer Ugur; Palanduz Sukru; Cefle Kivanc

doi:10.1515/tjb-2023-0042

Türk Biyokimya Dergisi (Jun 2023)

miR-145-5p suppresses cell proliferation by targeting IGF1R and NRAS genes in multiple myeloma cells

Kaya Murat,
Suer Ilknur,
Ozgur Emre,
Capik Ozel,
Karatas Omer Faruk,
Ozturk Sukru,
Gezer Ugur,
Palanduz Sukru,
Cefle Kivanc

Affiliations

Kaya Murat: Department of Internal Medicine, Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye
Suer Ilknur: Department of Internal Medicine, Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye
Ozgur Emre: Department of Basic Oncology, Diagnostic Treatment and Care Services, Oncology Institute, Istanbul University, Istanbul, Türkiye
Capik Ozel: Department of Molecular Biology and Genetics, Erzurum Technical University, Erzurum, Türkiye
Karatas Omer Faruk: Department of Molecular Biology and Genetics, Erzurum Technical University, Erzurum, Türkiye
Ozturk Sukru: Department of Internal Medicine, Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye
Gezer Ugur: Department of Basic Oncology, Diagnostic Treatment and Care Services, Oncology Institute, Istanbul University, Istanbul, Türkiye
Palanduz Sukru: Department of Internal Medicine, Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye
Cefle Kivanc: Department of Internal Medicine, Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye

DOI: https://doi.org/10.1515/tjb-2023-0042
Journal volume & issue: Vol. 48, no. 5
pp. 563 – 569

Abstract

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Multiple myeloma (MM) is a common hematological cancer. Hence, it is important to conduct further studies investigating the molecular mechanisms in detail that contributes to myeloma genesis. In addition to genetic changes, epigenetic factors such as miRNAs may influence the expression of myeloma-related genes.

Published in Türk Biyokimya Dergisi

ISSN: 1303-829X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.degruyter.com/journal/key/tjb/html

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