Nature Communications (Jun 2018)

Gut vagal sensory signaling regulates hippocampus function through multi-order pathways

  • Andrea N. Suarez,
  • Ted M. Hsu,
  • Clarissa M. Liu,
  • Emily E. Noble,
  • Alyssa M. Cortella,
  • Emily M. Nakamoto,
  • Joel D. Hahn,
  • Guillaume de Lartigue,
  • Scott E. Kanoski

DOI
https://doi.org/10.1038/s41467-018-04639-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Feeding-relevant vagal signaling occurs between the gastrointestinal tract and the brain, but it is unclear if this pathway influences cognitive processes. This study shows that endogenous gastrointestinal derived vagal sensory signaling promotes hippocampal-dependent memory function via a multi-order brainstem–septal pathway.