RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis

Linghua Yu; Linlin Wang; Xiaojun Wu; Huixing Yi

doi:10.1038/s42003-021-01747-5

Communications Biology (Feb 2021)

RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis

Linghua Yu,
Linlin Wang,
Xiaojun Wu,
Huixing Yi

Affiliations

Linghua Yu: Center for Gastroenterology and Hepatology, Institute of Liver Diseases, The Affiliated Hospital of Jiaxing College
Linlin Wang: Department of Basic Medicine Sciences, School of Medicine, Zhejiang University
Xiaojun Wu: Center for Gastroenterology and Hepatology, Institute of Liver Diseases, The Affiliated Hospital of Jiaxing College
Huixing Yi: Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University

DOI: https://doi.org/10.1038/s42003-021-01747-5
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Yu et al. demonstrates the role of RSPO4, a Wnt signaling agonist, in liver fibrogenesis and its impact on the gut microbiome. By knocking out RSPO4 gene in fibrotic-liver rat model, they show that it relieved liver fibrosis in rats and restored the microflora composition, highlighting its potential in liver fibrosis treatment.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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