Frontiers in Medicine (2021-02-01)

Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2

  • Daxi Wang,
  • Daxi Wang,
  • Yanqun Wang,
  • Wanying Sun,
  • Wanying Sun,
  • Wanying Sun,
  • Lu Zhang,
  • Lu Zhang,
  • Jingkai Ji,
  • Jingkai Ji,
  • Zhaoyong Zhang,
  • Xinyi Cheng,
  • Xinyi Cheng,
  • Xinyi Cheng,
  • Yimin Li,
  • Fei Xiao,
  • Airu Zhu,
  • Bei Zhong,
  • Shicong Ruan,
  • Jiandong Li,
  • Jiandong Li,
  • Jiandong Li,
  • Peidi Ren,
  • Peidi Ren,
  • Zhihua Ou,
  • Zhihua Ou,
  • Minfeng Xiao,
  • Minfeng Xiao,
  • Min Li,
  • Min Li,
  • Min Li,
  • Ziqing Deng,
  • Ziqing Deng,
  • Huanzi Zhong,
  • Huanzi Zhong,
  • Huanzi Zhong,
  • Fuqiang Li,
  • Fuqiang Li,
  • Fuqiang Li,
  • Wen-jing Wang,
  • Wen-jing Wang,
  • Yongwei Zhang,
  • Weijun Chen,
  • Weijun Chen,
  • Shida Zhu,
  • Shida Zhu,
  • Xun Xu,
  • Xun Xu,
  • Xin Jin,
  • Jingxian Zhao,
  • Nanshan Zhong,
  • Wenwei Zhang,
  • Jincun Zhao,
  • Jincun Zhao,
  • Junhua Li,
  • Junhua Li,
  • Junhua Li,
  • Yonghao Xu

DOI
https://doi.org/10.3389/fmed.2021.585358
Journal volume & issue
Vol. 8

Abstract

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The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.

Keywords